Alban Henry Griffiths Doran

Clinical and Pathological Observations on Tumours of the Ovary, Fallopian, Tube, and Broad Ligament (Classic Reprint)

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Alban Henry Griffiths Doran
   - Clinical and Pathological Observations on Tumours of the Ovary, Fallopian, Tube, and Broad Ligament (Classic Reprint)

Excerpt from Clinical and Pathological Observations on Tumours of the Ovary, Fallopian, Tube, and Broad Ligament

Physiology and Pathology' was the result of the examination of a large series of ovarian tumours removed by Sir Spencer Wells at the same institution.

In the chapter on the origin of multilocular ovarian cysts, I have described the result of repeated examinations of human f?tal, infantile, and adult ovaries prepared for me after different methods by different experts, and have given my reasons for believing that these tumours most probably arise from Graafian follicles that have never developed into corpora lutea. Under natural conditions such follicles undergo atrophy, but under certain morbid influences they develop into cysts. This point cannot be thoroughly settled till the verification or refutation of Dr. Foulis' theory that the cells lining the follicles arise from the stroma, and not from the germinal epithelium together with the ova. If this theory be perfectly correct, a purely stromal origin for cysts becomes possible. If the stroma normally produces cells to line cavities protecting ova, it is easy to understand that it may, under pathological influences, produce such cells where there are no ova. Under Balfour's theory, that the follicular cells arise with the ova from the germinal epithelium, each collection of such cells in the stroma must be considered to be a follicle, and any morbid growth from such cells would be of essentially follicular origin.

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